Counteracting muscle loss in clinical scenarios of disuse: insights from ‘simple’ human...

IAS Biddle Family Scholar Dr Chris McGlory delivers a seminar on their research, fully titled "Counteracting muscle loss in clinical scenarios of disuse: insights from ‘simple’ human experimental trials" -

Skeletal muscle is a vital organ, serving as a primary site for glucose and amino acid storage while generating the force required for movement. Across the lifespan, periods of skeletal muscle unloading due to injury, surgery, or illness are common. These episodes trigger rapid declines in skeletal muscle mass and strength, increasing the risk of metabolic dysfunction. This presentation will examine the cellular and molecular mechanisms underpinning skeletal muscle loss during disuse, with a particular focus on insights from controlled human experiments. Key differences between preclinical models, healthy human studies, and clinical populations will also be discussed, alongside advances in methodologies for assessing muscle protein turnover. The presentation will conclude by highlighting emerging strategies to attenuate disuse-induced atrophy and preserve muscle function.

Arrivals from 11:45 am for a 12:00 noon start. For those joining in-person, lunch will be served after the seminar from 1:00pm.

This event is hybrid format, please use the required booking button at the bottom of the page to choose either in-person or online attendance.
(Please note that in-person spaces are limited and booking is required, so we can manage numbers for catering and also the space in the seminar room)

By booking a place at this event, attendees agree to behave in a respectful manner such that everyone feels comfortable contributing as they wish. The IAS reserves the right to eject anyone who does not abide by this policy.

IAS seminars are typically recorded, minus any Q&A sessions at the end, again to encourage contributions. The recordings are then uploaded to our website on a Fellows bio page and/or Programme page, along with our IAS YouTube Channel. If you are not able to attend a seminar live, please do still register for the webinar anyway, as we will email everyone who registered to let them know once the recordings are made available.