Dr Jon Petzing

BEng (Hons), DIS, PhD

  • Senior Lecturer in Metrology
  • Director of Undergraduate Admissions

Research groups and centres

Publications

Dr Jon Petzing is the Senior Lecturer in Metrology at Loughborough within the Wolfson School of Mechanical, Electrical & Manufacturing Engineering. Originally training as a Stockbroker, Jon changed direction and studied Mechanical Engineering and worked for British Aerospace (now BAe Systems) specialising in the manufacture of missile systems.
Another change of direction resulted in Jon working with Nestlé and Loughborough University designing and developing in-process ultrasonic cutting systems for confectionary - and more specifically the optical metrology tools required to measure the performance of these cutting tools.

Jon then joined the Loughborough University Department of Mechanical Engineering academic staff in 1996 as the NPL Lecturer in Optical Engineering, before joining the Department of Manufacturing Engineering as the Lecturer in Metrology and subsequently Senior Lecturer in Metrology within the Wolfson School.

Qualifications

  • Loughborough University, Doctor of Philosophy (PhD), Optical Metrology, UK, 1991 - 1996
  • Loughborough University, Bachelor of Engineering (BEng (Hons)), Mechanical Engineering, UK, 1987 - 1991
  • Loughborough University, Diploma of Industrial Studies (DIS), UK, 1990 – 1991

Key Awards

  • Chartered Engineering (CEng), Institution of Mechanical Engineers (IMechE), 2005 - Present
  • Fellow of the Higher Education Academy (FHEA), 2018 - Present
  • Helmut N Friedlaender Award for Leadership, Ametek Inc, 2010

Jon’s applied research is concerned with; biometrology, contact and non-contact dimensional metrology, surface metrology, optical metrology, acoustic metrology, pressure metrology and metrology standards, much of which is in the context of High Value Manufacturing engineering.

Jon’s work encompasses measurement instrument development / design, industrial integration, measurement confidence, standards and metrology guides, with over 20 PhD Doctoral Researchers resulting in over 190 scholarly articles and publications. His most recent research is investigating variation in biometrology – specifically Flow Cytometry, as an underpinning definition of data confidence to inform biomanufacturing process control. This is examining variation of metrology data analysis, both from a human operator perspective and from an automated software viewpoint.

Jon is responsible for the development of the Loughborough University dedicated UKAS standard Advanced Dimensional Metrology Laboratory amounting to £1.2m of metrology equipment investment to date. He was a Scientific Advisory Board member for the UK Centre of Excellence in Metrology for Micro and Nano Technologies (CEMMNT) (2007 – 2009), and has had research collaborations with the Australian (CSIRO), Malaysian (SIRIM), UK (NPL & LGC) National Measurement Institutes. He was a member of the National Measurement Office Engineering & Flow Working Group (2012 - 2015), responsible for steering UK metrology research and allocation of £10m+ pa (NPL and NEL). Jon is now a member of the BSI Committee – BTI Biotechnology advising on aspects of biometrology for ISO TC276 standards development.

Grants and Contracts

The following are research grants and projects over the last 10+ years where Jon has been either Principle Investigator or a Co-Investigator;

  • 2020 – Present, “Midlands Centre for Data-Driven Metrology”, Research England Development Fund
  • 2019 – 2021, “Integrated atomic force and confocal fluorescence lifetime imaging microscope with fibre-coupled infrared detector for materials research”, EPSRC
  • 2018 – 2021, “Defining confidence in Flow Cytometer automated data analysis software platforms in the context of manufacturing process control”, LGC Ltd
  • 2017 – 2018, “Underpinning Multi-User Equipment”, EPSRC
  • 2016 – 2019, “The application of manufacturing metrology strategies for the control of large scale bio-manufacturing of stem cell therapies”, GSK and LGC Ltd
  • 2015 – 2016, “Cell Microfactories: Feasibility Study in the Re-distributed Manufacture of Cell-Based Therapeutics”, EPSRC
  • 2015 – 2018, In Jet Interferometry for Ultra Precise Electrolyte Jet Machining”, EPSRC
  • 2013 – 2016, “Turbine blade vibration monitoring instrumentation”, KTP Award
  • 2011 – 2017, “EPSRC Centre for Innovative Manufacturing in Intelligent Automation”, EPSRC
  • 2010 – 2016, “EPSRC Centre for Innovative Manufacturing in Regenerative Medicine”, EPSRC
  • 2010 – 2013, “Development of an optical micro CMM”, Alicona GmbH and UK National Physical Laboratory (NPL)

Teaching Responsibilities

The following are current teaching responsibilities across various degree programmes;

  • WSA502 Applied Sports Technology
  • WSA505 Integrating Studies
  • WSA508 Engineering Principles and Professional Skills
  • WSA610 Manufacturing Technology (Module Leader)
  • WSB310 Engineering & Management Modelling (Module Leader)
  • WSB504 Application of Product Design
  • WSB610 Manufacturing Technology (Module Leader)
  • WSC603 Metrology (Module Leader)

Administrative Responsibilities

  • Director of Undergraduate Admissions; shared responsibility of administering and recruiting new undergraduate students to all of the eight undergraduate degree programmes within the Wolfson school

Recent Conference papers

  • T Hovell, L Justham, J Petzing, P Kinnell, “In-situ measurement of electrochemical jet machining using low coherence interferometry”, Euspen 20th International Conference, Geneva, Switzerland, 8th – 12th June 2020
  • M Cheung, J Campbell, J Braybrook, R Thomas, J Petzing, “Benchmarking automated flow cytometry data analysis software using synthetic datasets”, ISCT International Society for Cell & Gene Therapy Conference, Paris, France, May 2020,
  • R Grant, K Coopman, N Medcalf, S Gomes, J Campbell, J Braybrook, J Petzing, “Applying uncertainty analysis to assess the variation of operator performance when manually gating Flow Cytometry data”, ISCT International Society for Cell & Gene Therapy Conference, Paris, France, May 2020
  • M Cheung, J Campbell, J Braybrook, R Thomas, J Petzing, “Benchmarking automated flow cytometry data analysis software using synthetic datasets”, EPSRC and MRC CDTs – Future Leaders Virtual Conference 2020, University of Manchester, Manchester, UK, 2020
  • M Cheung, J Campbell, J Braybrook, R Thomas, J Petzing, “Evaluation of flow cytometry automated data analysis platform performance for rare event detection”, Cyto Virtual 2020, International Society for the Advancement of Cytometry, Philadelphia, USA, August 2020
  • T Hovell, L Justham, J Petzing, P Kinnell, “Multiscale calibration of a low-coherence interferometer for embedded metrology”, Euspen 21st International Conference, Copenhagen, Denmark, June 2020
  • M Cheung, J Campbell, R Thomas, J Braybrook, J Petzing, “Assessment of computational tools for automated flow cytometry data analysis within cell and gene therapy manufacturing”, EPSRC and MRC CDTs – Future Leaders in Regenerative Medicine: Joint Conference CDTs and UKSB, University of Glasgow, Glasgow, UK, June 2021
  • C Pottier, J Petzing, P Kinnell, “Blender – A 3D animation software explored as a metrology tool”, 3DMC 2021 conference, Bilbao, Spain, Nov 2021
  • M Cheung, J J Campbell, R J Thomas, P Moore, L Whitby, J Braybrook, J Petzing, “Comparability between manual and automated methods for flow cytometry data analysis”, 18th Annual BioProcessUK Conference 2021, Cardiff, November 2021
  • J Petzing, “Flow cytometry applied to cell analysis and therapies – why is there variation in the metrology?”, Midlands Innovation Flow Cytometry Meeting, Loughborough University, April 2022

Recent Journal papers

  • R Grant, K Coopman, N Medcalf, S Silva-Gomes, J Campbell, B Kara, J Braybrook, J Petzing, “Understanding the contribution of operator measurement variability within flow cytometry data analysis for quality control of cell and gene therapy manufacturing”, Measurement, 150, 106998, 2020, doi.org/10.1016/j.measurement.2019.106998
  • J Thurman-Newell, J Petzing, D J Williams, “Establishing the range of variation, outliers and regional variation of blood metrics within UK Biobank to inform the design of cell therapy manufacturing processes”,
  • Future Science Journal of Regenerative Medicine, 14(11), 2019, doi.org/10.2217/rme-2018-0168
  • T Hovell, R S Matharu, J Petzing, L Justham, P Kinnell, “Lenless fibre-deployed low coherence interferometer for in-situ measurements in harsh environments”, Optical Engineering. 59(1), 014113, 2020, doi.org/10.1117/1.OE.59.1.014113
  • T Hovell, J Petzing, L Justham, P Kinnell, “From light to displacement; a design framework for transducer spectral-domain low-coherence interferometric sensors for in-situ measurement”, MPDI Journal of Applied Science, 10(23), 8590, 2020, doi.org/10.3390/app10238590
  • M Cheung, J Campbell, L Whitby, R Thomas, J Braybrook, J Petzing, “Current trends on flow cytometry automated data analysis software”, Cytometry A, 99(10), 1007-1021, 2021, doi.org/10.1002/cyto.a.24320
  • R Grant, K Coopman, N Medcalf, S Silva-Gomes, J Campbell, B Kara, J Braybrook, J Petzing, “Quantifying operator subjectivity within Flow Cytometry Data Analysis as a source of measurement uncertainty and the impact of experience on results”, PDA Journal of Pharmaceutical Science and Technology, 75(1) 33-47, 2021, doi.org/10.5731/pdajpst.2019.011213
  • R Grant, K Coopman, S Silva-Gomes, J Campbell, B Kara, J Braybrook, J Petzing, “Assessment of protocol impact on subjectivity uncertainty when analyzing Peripheral Blood Mononuclear Cell data files”, MDPI Journal of Methods & Protocols, 4(2), 24, 2021, doi.org/10.3390/mps4020024
  • B He, P Webb, J Petzing, “Areal surface texture parameters for copper/glass plating adhesion characteristics”, Measurement Science Review, 21(1), 11-18, 2021, doi.org/10.2478/msr-2021-0002
  • T Hovell, J Petzing, L Justham, P Kinnell, “Pragmatic micrometre to millimetre calibration using multiple methods for low-coherence interferometer in embedded metrology”, MDPI Journal of Sensors, 21, 5101, 2021, doi.org/10.3390/s21155101
  • M Cheung, J Campbell, L Whitby, R Thomas, J Braybrook, J Petzing, “Systematic design, generation, and application of synthetic datasets for flow cytometry”, PDA Journal of Pharmaceutical Science and Technology, 76(3), 1-16, 2022, doi.org/10.5731/pdajpst.2021.012659
  • M Cheung, J Campbell, R Thomas, J Braybrook, J Petzing, “Assessment of automated flow cytometry data analysis tools within cell and gene therapy manufacturing”, MPDI International Journal of Molecular Sciences, 23(6), 3224, 2022, doi.org/10.3390/ijms23063224
  • C Newman, J Petzing, M Goh, L Justham, “Investigating the optimisation of real-world and synthetic object detection training datasets through the consideration of environmental and simulation factors”, Journal of Intelligent Systems with Applications, doi.org/10.1016/j.iswa.2022.200079

Selected Publications

  • A R Harland, J N Petzing, J R Tyrer, “Nonperturbing measurements of spatially distributed underwater acoustic fields using a scanning laser Doppler vibrometer”, Journal of the Acoustical Society of America, 115(1), 187-195, 2004, doi.org/10.1121/1.1635841
  • W S Wan Abdullah, J N Petzing, “Development of speckle shearing interferometer error analysis as an aperture function of wavefront divergence”, Journal of Modern Optics, 52(11), 1495-1510, 2005, doi.org/10.1080/09500340500052887
  • F Gao, R K Leach, J N Petzing, J M Coupland, “Surface measurement errors using commercial scanning white light interferometers”, Measurement Science & Technology, 19, 015303, 2008, doi.org/10.1088/0957-0233/19/1/015303
  • W A M Wan Mohamed, J N Petzing, “The development of novel interchangeable pistons for pressure performance optimization in a gas-operated dead weight pressure balance”, Metrologia, 46, 315-322, 2009, doi.org/10.1088/0026-1394/46/3/020
  • J A Thurman-Newell, J Petzing, D Williams, “Quantification of biological variation in blood-based therapies: A summary of a meta-analysis to inform manufacturing in the clinic”, Vox Sanguinis, 109(4), 394-402, 2015, doi.org/10.1111/vox.12288
  • J A Thurman-Newell, J Petzing, D Williams, “A Meta-analysis of biological variation in blood-based therapy as a precursor to biomanufacturing”, Cytotherapy, 18(5), 686-694, 2016, doi.org/10.1016/j.jcyt.2016.01.011
  • T Hovell, J Petzing, L Justham, P Kinnell, “From light to displacement; a design framework for ransducer spectral-domain low-coherence interferometric sensors for in-situ measurement”, MPDI Journal of Applied Science, 10(23), 8590, 2020, doi.org/10.3390/app10238590
  • M Cheung, J Campbell, L Whitby, R Thomas, J Braybrook, J Petzing, “Current trends on flow cytometry automated data analysis software”, Cytometry A, 99(10), 1007-1021, 2021, doi.org/10.1002/cyto.a.24320
  • R Grant, K Coopman, S Silva-Gomes, J Campbell, B Kara, J Braybrook, J Petzing, “Assessment of protocol impact on subjectivity uncertainty when analyzing Peripheral Blood Mononuclear Cell data files”, MDPI Journal of Methods & Protocols, 4(2), 24, 2021, doi.org/10.3390/mps4020024
  • T Hovell, J Petzing, L Justham, P Kinnell, “Pragmatic micrometre to millimetre calibration using multiple methods for low-coherence interferometer in embedded metrology”, MDPI Journal of Sensors, 21, 5101, 2021, doi.org/10.3390/s21155101
  • M Cheung, J Campbell, R Thomas, J Braybrook, J Petzing, “Assessment of automated flow cytometry data analysis tools within cell and gene therapy manufacturing”, MPDI International Journal of Molecular Sciences, 23(6), 3224, 2022, doi.org/10.3390/ijms23063224
  • J N Petzing, J M Coupland & R Leach, NPL Measurement Good Practice Guide No.116, “The Measurement of Rough Surface Topography using Coherence Scanning Interferometry”, National Physical Laboratory, HMSO, 133 pages, December 2010, ISSN 1368-6550

External Collaborators

  • LGC Ltd (Laboratory of the Government Chemist, Teddington, UK
  • UK National External Quality Assessment Service for Leucocyte Immunophenotyping (UK NEQAS-LI), Sheffield, UK
  • GSK, Stevenage
  • SciTek Consultants Ltd, Derby, UK
  • Campbell Scientific Ltd, Shepshed, UK
  • UK National Physical Laboratory (NPL), Teddington, UK
  • Alicona Imaging GmbH, Graz, Austria
  • Standard and Industrial Research Institute of Malaysia (SIRIM Berhad), Malaysia
  • Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia

External roles and appointments

  • BTI/001 Biotechnologies British Standards Institute Committee Member